Vaginal prolapse: how do completely different surgical approaches evaluate?


On this weblog for clinicians, our Senior Fellow in Normal Follow, Lynda Ware, summarizes the most recent Cochrane proof on surgical approaches for vaginal prolapse and Simon Jackson, Marketing consultant Gynaecologist at Oxford’s John Radcliffe Hospital, displays on why this overview is well timed.

It’s estimated that as many as 50% of ladies who’ve had kids expertise a point of pelvic organ prolapse. This systematic overview by the Cochrane Gynaecology and Fertility Group seems on the security and effectiveness of transvaginal mesh or organic grafts in comparison with native tissue restore for vaginal prolapse.

What did the overview discover?

The overview included 37 RCTs, involving 4023 contributors. The standard of the proof ranged from very low to average. The primary limitations have been poor reporting of research strategies, inconsistency and imprecision.

discussing approaches to vaginal prolapse

Totally different approaches to surgical procedure for vaginal prolapse: there are dangers and advantages to be weighted up, and uncertainties stay

There appeared be benefits to utilizing everlasting mesh when in comparison with native tissue restore in decrease charges of consciousness of prolapse (average high quality proof), repeat surgical procedure for prolapse (average high quality proof) and recurrent prolapse on examination (low high quality proof). Nevertheless, extra ladies within the mesh group wanted repeat surgical procedure for the mixed end result of prolapse, stress incontinence or mesh publicity (average high quality proof). Everlasting mesh was related to larger charges of de novo stress incontinence (low high quality proof) and bladder damage (average high quality proof). There was no proof of a distinction in de novo dyspareunia (low high quality proof). The consequences on high quality of life have been unsure as a consequence of very low-quality proof.

Within the comparisons between absorbable mesh versus native tissue restore and organic graft versus native tissue restore the proof for all reported outcomes was low or very low high quality. There was restricted proof that absorbable mesh could cut back the charges of recurrent prolapse on examination.

Authors’ Conclusions

The authors concluded that the danger/profit profile of everlasting mesh limits its use in major surgical procedure. Absorbable mesh could cut back the charges of recurrent prolapse on examination however there was inadequate proof to attract significant conclusions on different outcomes. There was additionally inadequate proof to remark confidently on the comparability of organic grafts with native tissue restore.

It’s vital that many transvaginal everlasting meshes have been voluntarily withdrawn from the market in 2011. Newer, light-weight transvaginal everlasting meshes that are nonetheless obtainable haven’t been evaluated inside a RCT.

Simon Jackson, Marketing consultant Gynaecologist, writes:

This overview is well timed; there’s at present a lot debate in regards to the function of mesh in pelvic ground reconstructive surgical procedure. Vaginal and uterine prolapse is a particularly widespread downside, and repairing tissue whereas preserving regular perform is difficult. The primary aetiology is childbirth and weak connective tissue; with out strengthening tissue on the time of surgical restore failure charges are excessive.

Mesh surgical procedure was launched in an effort to cut back the excessive prolapse recurrence charges we all know happen after native tissue surgical restore, whereas minimising excision of wholesome vaginal tissue, and therefore sustaining regular sexual perform.

Nevertheless, mesh implant has been related to problems equivalent to erosion into adjoining organs, and mesh extrusion inside the vagina. A few of these problems have been operator dependent, others have been real mesh implant problems.

These problems have been broadly reported in each medical literature and the lay press. There was excessive profile and very costly litigation, notably within the USA. There have additionally been political directives issued in Scotland which have been broadly reported.

Consequently there was a transfer away from mesh implant, with trade withdrawing some merchandise from the market.

“We want a mature proof based mostly dialogue with our sufferers”

We are actually in a scenario the place surgical procedure, deserted within the 1990’s as a consequence of poor efficacy, is being reintroduced. Industrial innovation is ceasing. We want a mature proof based mostly dialogue with our sufferers, who need to determine between non mesh or mesh surgical procedure. We additionally want proof on the relative deserves of vaginal versus belly vaginal reconstruction.

This Cochrane overview strikes the talk forwards in a optimistic method and will probably be welcomed by each clinicians and sufferers.

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Vaginal prolapse: how do completely different surgical approaches evaluate? by Lynda Ware is licensed beneath a Creative Commons Attribution-NoDerivatives 4.0 International License.
Primarily based on a piece at Pictures have been bought for Evidently Cochrane from and will not be reproduced.


Maher CFeiner BBaessler OkayChristmann-Schmid CHaya NMarjoribanks JTransvaginal mesh or grafts compared with native tissue repair for vaginal prolapseCochrane Database of Systematic Evaluations 2016, Subject 2. Artwork. No.: CD012079. DOI: 10.1002/14651858.CD012079.

Plain language abstract:

Cindy Farquhar. No implementation with out analysis: the case of mesh in vaginal prolapse surgical procedure[editorial]. Cochrane Database of Systematic Evaluations 2016;(2): 10.1002/14651858.ED000108. Accessible from:

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